Xtra-Cell Comitris NF™ provided by Douglas Laboratories®, is an innovative non-frozen marine liquid cartilage extract (LCE) containing water-soluble proteins and peptides designed to help maintain healthy angiogenic balance, as well as joint health and mobility. Xtra-Cell Comitrisnf also provides a convenient way to maintain protocols while traveling.

FUNCTIONS
Xtra-Cell Comitris NF™ is manufactured and purified via a patented† low temperature extraction and molecular ultrafiltration of shark cartilage that does not involve the use of excipients, chemicals, enzymes or preservatives. This extraction process allows for the selection of molecules based on their size and weight, and results in a finished extract that is composed of proteins, peptide and other compounds having approximate molecular weights of less than 500 kilodaltons (kDa). After extraction, the liquid is aseptically bottled and each batch is tested for potency and purity according to validated methods. Bioavailability of the extract has been assessed by a human clinical trial. Xtra-Cell Comitris NF™ has a pleasant orange/vanilla flavor.

Angiogenesis is a natural process by which new blood vessels are formed and grow to supply oxygen and nutrients to cells. Angiogenesis is a complex process that is regulated at the cellular level with a balance between factors that are proangiogenic and factors that are anti-angiogenic. Disturbances in this balance can effect the health of a tissue. Maintaining the integrity of the extracellular matrix (a meshwork of protein fibers such as collagen and elastin plus polysaccharides including chondroitin sulfate and hyaluronic acid) is critical for allowing the transportation of nutrients, and for providing structure to cartilage, muscles sheaths, skin, and tendons. The normal breakdown and regeneration of the extracellular matrix is required for proper tissue health. However, excessive breakdown can lead to deterioration of the matrix. Liquid cartilage extract may help to maintain the structure and function of the extracellular matrix as well as blood vessels and tissues by supporting the proper activity of a family of zinc-dependent enzymes known as matrix metalloproteinases (MMPs). Specifically MMP-2
MMP-9, and MMP-12 (also know as gelatinase A gelatins B, and metalloelastase, respectively) have been shown to be involved in both the breakdown of the extracellular matrix as well as the breakdown of vascular basement membranes. An imbalance in MMP activity can alter angiogenic balance.

Another molecule that plays a central role in maintaining angiogenic balance is a compound called vascular endothelial growth factor (VEGF). When bound to one of its two receptors, VEGF can stimulate endothelial cell proliferation, affect cell permeability, and contribute to the formation of new blood vessels. Together, the actions of LCE an MMP activity and VEGF binding can work in concert to maintain healthy angiogenic processes.


A more recently observed characteristic of LCE is its ability to support healthy blood parameters.

INDICATIONS
Xtra-Cell Comitris NF™ non-frozen may be a useful dietary supplement for those who wish to support healthy angiogenic balance. Xtra-Cell Comitrisnf non-frozen may also be useful to help support healthy hematocrit.