Vitamin C Supreme

High Potency Vitamin C in a Natural Citrus Flavored Drink

with a complete Bioflavonoid Complex

Serve Hot or Cold!

Vitamin C Supreme

DESCRIPTION

Vitamin C Supreme, supplies 3,000 mg of Vitamin C
with a complete Bioflavonoid complex per scoop.

FUNCTIONS

Vitamin C (ascorbic acid) has numerous biological functions. Foremost, it is essential for the synthesis of collagen and glycosaminoglycans which are the building materials of all connective tissues, such as skin, blood vessels, tendons, joint cartilage and bone.

Vitamin C is the required coenzyme for two groups of enzymes that catalyze the crosslinking of collagen fibers - lysyl hydroxylases and prolyl hydroxylases. As such, vitamin C is essential for normal wound healing and capillary health. It also participates in the biosynthesis of carnitine, serotonin, and certain neurotransmitters, including norepinephrine.

Vitamin C is among the most powerful antioxidants in humans and animals. It is a water-soluble, chain breaking antioxidant that reacts directly with superoxide, hydroxyl radicals, and singlet oxygen.Laboratory studies show that vitamin C completely protects lipids in plasma and low-density lipoprotein (LDL) against atherogenic peroxidative damage. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and regenerates vitamin E. The antioxidant functions of vitamin C appear to have clinical significance in providing protection from free

radical damage to the eyes, lungs, blood and the immune system.

Vitamin C is absorbed in the small intestine by a sodium-dependent transport process that is intake dependent. At normal dietary intakes of 60 to 100 mg, up to 80 or 90% of the vitamin C is absorbed. At higher intakes, absorption becomes less efficient.

Absorption efficiency and vitamin C utilization may be greatly enhanced during conditions of physiological stress, such as trauma or infection.

Bioflavonoids (also called flavonoids) are a class of phytochemicals that are potent antioxidants, which scavenge many potentially damaging free radicals.

Free radicals are unstable chemicals formed in the body during metabolism and from exposure to environmental sources, such as pollution and cigarette smoke. Free radicals are produced during energy metabolism and are necessary for immune function, but when an excessive number of free radicals are formed, they can attack healthy cells, especially their membrane lipids and proteins. This, in turn, is thought to contribute to a degradation of the structure and function of these cellular components.

Another aspect of the antioxidant properties of bioflavonoids is their synergy with vitamin C. The bitter tasting flavanones hesperidin and naringin, from the white albedo layer of citrus peels, have been shown to extend the nutritional functions of vitamin C.

Bioflavonoids are also capable of binding to metal ions, which prevents these metals from acting as catalysts in the body to enhance free radical production.

Many bioflavonoids, especially rutin and quercetin, support the health of the body�s circulatory system by helping maintain capillary blood flow and proper vascular permeability, integrity, and resiliency.

Bioflavonoids are also involved in a wide array of other biochemical functions, such as immune function, platelet aggregation, enzyme activity, and the metabolism of collagen, cholesterol, and histamine.

INDICATIONS

Vitamin C Supreme may be a useful dietary supplement for individuals wishing to supplement their diet with vitamin C.

FORMULA (#CSUP)

Each Scoop Contain:

Vitamin C 3000 mg

Lemon Bioflavonoids 100 mg

Rose Hips 100 mg

Hesperidin Complex 100 mg
Rutin 75 mg

Calicuim 20 mg

Other ingredients
Honey, Fructose, and Natural Orange flavor

REFERENCES
Anderson JW, Gowri MS, Turner J, et al. Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with type 2 diabetes mellitus. J Am Coll Nutr 1999;18:451-61.Ascherio A, Rimm EB, Hernan MA, et al. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999;130:963-70.Brennan LA, Morris GM, Wasson GR, et al. The effect of vitamin C or vitamin E supplementation on basal and H2O2- induced DNA damage in human lymphocytes. Br J Nutr 2000;84:195-202.Hamilton IM, Gilmore WS, Benzie IF, et al. Interactions between vitamins C and E in human subjects. Br J Nutr 2000;84:261-7.Masaki KH, Losonczy KG, Izmirlian G, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54:1265-72.Otsuka M, Matsuzawa M, Ha TY, et al. Contribution of a high dose of L-ascorbic acid to carnitine synthesis in guinea pigs fed high-fat diets. J Nutr Sci Vitaminol (Tokyo) 1999;45:163-71.Schroder H, Navarro E, Tramullas A, et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med 2000;21:146-50.Simon JA, Hudes ES. Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults: the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol 1999;9:358-65.Ushakova T, Melkonyan H, Nikonova L, et al. Modification of gene expression by dietary antioxidants in radiation- induced apoptosis of mice splenocytes. Free Radic Biol Med 1999;26:887-91.Victor VV, Guayerbas N, Puerto M, et al. Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology 2000;46:89-101.

Afanas'ev IB, Ostrachovitch EA, Abramova NE, Korkina LG. Different antioxidant activities of bioflavonoid rutin in normal and iron-overloading rats. Biochem Pharmacol 1995;50:627-35. Bors W, Michel C, Schikora S. Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study. Free Radic Biol Med 1995;19:45-52. Conquer JA, Maiani G, Azzini E, Raguzzini A, Holub BJ. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr 1998;128:593-7. de Whalley CV, Rankin SM, Hoult JR, Jessup W, Leake DS. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biochem Pharmacol 1990;39:1743-50. Ferrandina G, Almadori G, Maggiano N, Lanza P, Ferlini C, Cattani P, Piantelli M, Scambia G, Ranelletti FO. Growth-inhibitory effect of tamoxifen and quercetin and presence of type II estrogen binding sites in human laryngeal cancer cell lines and primary laryngeal tumors. Int J Cancer 1998;77:747-54. Grinberg LN, Rachmilewitz EA, Newmark H. Protective effects of rutin against hemoglobin oxidation. Biochem Pharmacol 1994;48:643-9. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-11. Hertog MG, Hollman PC, Katan MB, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 1993;20:21-9. Hirano T, Gotoh M, Oka K. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci 1994;55:1061-9. Keli SO, Hertog MG, Feskens EJ, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 1996;156:637-42. Lee SC, Kuan CY, Yang CC, Yang SD. Bioflavonoids commonly and potently induce tyrosine dephosphorylation/inactivation of oncogenic proline-directed protein kinase FA in human prostate carcinoma cells. Anticancer Res 1998;18:1117-21. Manach C, Morand C, Texier O, Favier ML, Agullo G, Demigne C, Regerat F, Remesy C. Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J Nutr 1995;125:1911-22. Middleton E, Jr. Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 1998;439:175-82. Negre-Salvayre A, Mabile L, Delchambre J, Salvayre R. alpha-Tocopherol, ascorbic acid, and rutin inhibit synergistically the copper-promoted LDL oxidation and the cytotoxicity of oxidized LDL to cultured endothelial cells. Biol Trace Elem Res 1995;47:81-91. Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 1995;22:375-83. Saija A, Scalese M, Lanza M, Marzullo D, Bonina F, Castelli F. Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic Biol Med 1995;19:481-6. Schmitt A, Salvayre R, Delchambre J, Negre-Salvayre A. Prevention by alpha-tocopherol and rutin of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells. Br J Pharmacol 1995;116:1985-90.