Atri-Flav 1000 - 90 Tablets - Atrium
Spleen glandular concentrate is added to provide specific nutrient support for the spleen. The spleen plays a vital role in immunity. Persons with splenectomy or poor spleen function secondary to trauma may benefit by glandular nutrient specific nutritional support. The spleen constituents tufsin and splenopentin have demonstrated potent immune enhancing activity. Tuftsin has demonstrated increased macrophage production activity and assists other white cells with fighting infections. Splenopentin has been shown to enhance the body's response to "colony-stimulating factors" such as interleukin-3 and granulocyte/macrophage colony-stimulating factors which increases white blood cell production and enhance natural killer cell activity.
Many animal and human studies irrefutably confirm the absorption of large macromolecules through the gut following oral administration, including whole proteins, enzymes, and various hormones, strongly supporting the use of glandular consumption as a nutrient-specific organ-targeted nutritional therapeutic measure.
Vitamin C is a hexose derivative and a term generally applied to 2 compounds and their salts that possess antiscorbutic activity and includes L-ascorbic acid and dehydroascorbic acid and although ascorbic acid is the major dietary form, the term vitamin C is used interchangeably with L-ascorbate or ascorbate. Humans require a dietary intake of vitamin C because they lack the enzyme L-gulano-gamma-lactone oxidase which is the last step in synthesizing vitamin C from glucose. Although the major deficiency disease associated with low vitamin C levels is scurvy, a myriad of symptoms can manifest including bleeding gums, impaired healing, joint pain, muscle weakness and pain, fatigue, anemia, diarrhea, anorexia, dry eyes and mouth, kidney and pulmonary problems, coma and death. Albert Szent-Gyorgyi first discovered vitamin C looking for reducing substances in the adrenal cortex and one of the isolates he named C XII, which later became known as ascorbic acid.
Vitamin C is important in the biochemistry of the formation of connective tissues, i.e. collagen, elastin, fibrillin, fibronectin, proteoglycans, and bone matrix. It also is important in the collagen gene expression and procollagen cellular secretion. The carnitine biosynthetic pathway requires vitamin C as a co-factor for completion, therefore muscle weakness associated vitamin C deficiency is related to reduced levels of muscle carnitine. Ascorbic acid also modulates iron cellular storage via ferritin synthesis, promotes iron release from the intestines, and plasma transportation. The biosynthesis of corticosteroids, aldosterone, conversion of cholesterol to bile acids, and many biochemical reductions, including mixed-function oxidases are vitamin C dependant, but vitamin C is perhaps the most important water-soluble anti-oxidant best known for its probable anti-oxidant role in preventing chronic diseases, such as coronary heart disease and cancer by detoxifying anthracenes and heavy metals, especially lead via chelation or preventing carcinogenic formation of nitosamines.
Vitamin C is known for its anti-oxidant activity of scavenging free-oxygen radicals and reactive nitrogen species playing and important role in tissue injury response, inhibiting lipid peroxidation, DNA oxidative damage, as well as protecting proteins from oxidative damage. It is a co-factor for certain biochemical reactions that reduce the transition metals, copper and iron and promotes the synthesis of NO and EDRF and prevents the oxidation of LDL, which is thought to be a factor in the atherogenesis of arterial plaquing. Vitamin C also is thought to modulate prostaglandin in favor of eicosanoids that possess anti-thrombotic and vasodilatory activity while sparing vitamin E. Vitamin C can also inhibit the growth of H. pylori, the bacteria associated with gastric ulcers.
Studies also show favorable pro-oxidant effects involved in DNA repair mechanisms with ascorbic influence on inhibition of HIV-1, in vitro, with some evidence that it reduces the incidence, severity and duration of the common cold. Vitamin C exhibits anti-histamine activity and may protect against asthma, allergens, viral infections and other lung irritants that can lead to bronco-constriction. Vitamin C may help prevent cataracts and has greater anti-infective potential than previously believed and may reduce the incidence of gall bladder disease and the risk of type 2 diabetes mellitus onset as well as evidence based helpfulness in the treatment of Charcot-Marie-Tooth disease that affects 1 in 2,500 people with hereditary peripheral neuropathy.
Intestinal absorption of vitamin C is completely absorbed by the intestines at 30 mgs per day, but decreased absorption is noted with higher dosing, for example only 50% is absorbed at 1.5 grams intake with only 16% absorbed at 12 grams intake level. Vitamin C absorption is sodium dependant with distribution noted throughout the body, but higher concentrations are found in the adrenal glands, brain and white cells. It is my opinion that 2,000 mg spread over the day is an appropriate dosing for vitamin C and the recent "scares" about high dosing of vitamin C are unfounded except with iron-overloading in certain persons, although it may certainly cause diarrhea and intestinal bloating.
Bioflavonoids, usually include rutin, hesperidin, quercitin and naringin, and are added to enhance the anti-oxidant effect and help stabilize vitamin C with studies confirming enhanced intra-cellular absorption, reduced capillary fragility and increased permeability. Most of the recent studies have been performed using hydroxyethylrutosides (HER), which is more potent than natural bioflavonoids, but extraplolated data is consistent with the effects of bioflavonoids as assisting in the anti-allergic and anti-inflammatory response, inhibiting platelet aggragation, and their free radical scavaging protective effect on tissues and cells.
Since certain organs contain bio-chemicals, precursors, and organ specific hormones as well as other tissue components, persons with known sensitivities to any organ specific bio-chemical, hormone or the tissue itself should exercise caution. I strongly recommend that the use of glandular therapy be under the supervision of a qualified health-care professional because there may be other very important health issues to consider along with blood laboratory assessment.
Aspirin may reduce vitamin C levels and vitamin C may potentiate chemotherapeutic drugs. Ascorbic acid may also enhance 17 beta-estradiol inhibition of oxidatized LDL cholesterol formation. Consult with your physician if you are taking any of the above medications, including calcium channel blockers and the cholesterol lowering statins. Side-effects of vitamin C are rare, but allergic reactions to vitamin C and its constituents have been reported, including increasing complications in indivuals with kidney problems. Elevated glucose levels have been reported with comsumption of 4.5 grams per day. One reported case of vitamin C induced hyper-oxaluria was reported in 2008, resulted in renal failure and death. Discuss with your physician or pharmacist vitamin C's influence on iron absorption if you are prone to iron overload or have sickle cell or sideroblastic anemia, thalassemia or erythrocyte G6PD deficiencies.
,© 2009 W.G. Morrow, PhD, DC