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Vitamin A Supreme
Vitamin A Supreme
powerful antioxidant protection




 

DESCRIPTION

Vitamin A, provided by Nutrition Dynamics®, contains 10,000 I.U. per softgel of 100% natural vitamin A derived from fish liver oil.

FUNCTIONS

Vitamin A (retinol) is a fat-soluble vitamin essential for vision, growth, reproduction, cell division, and the integrity of the immune system.

The most well-known function of vitamin A is its role in vision.  As part of the membrane-bound visual protein rhodopsin, vitamin A is essential in the eyes for converting light into nerve impulses. Night blindness and xeropthalmia are signs of moderate to severe vitamin A deficiency.  Xerophthalmia is a common cause of preventable blindness in many underdeveloped countries around the world.
 

Vitamin A is essential for normal cellular differentiation.  Its metabolite, retinoic acid, assumes a central role in gene activation and transcription.  As a result, vitamin A status has profound effects on all rapidly dividing tissues in the body, such as immune cells and intestinal cells, and affects fertility, fetal development and growth.
 

Cellular differentiation is crucial for normal immune response, and vitamin A deficiency can start a vicious cycle affecting the immune system.  During vitamin A deficiency, immune function is impaired, which puts the body at increased risk for infections.  Acute infections further deplete the body of vitamin A, which leads to an even more impaired immune function and an even lower resistance to infections.
 

While a few studies have found that vitamin A status in developed populations may be adequate, many studies showed that marginal vitamin A deficiency is quite common.  Women often have lower vitamin A levels than men - who tend to consume more meats high in vitamin A.  The elderly are also at increased risk for marginal vitamin A deficiency.  Persons with HIV infection or AIDS often have low serum vitamin A and are at high risk for moderate to severe vitamin A deficiency.

 

The intestinal absorption of vitamin A is associated with fat absorption.  Therefore, some dietary fat must be present for efficient vitamin A absorption to occur.

INDICATIONS

Vitamin A may be a useful dietary supplement for those who wish to increase their daily vitamin A intake and provide this important vitamin in its natural form.

FORMULA  (ASUP)

Each softgel contains:    

Vitamin A (from fish liver oil)............ 10,000. I.U.

SUGGESTED USE

One softgel daily with a meal, or as directed by physician.

SIDE EFFECTS

No adverse side effects have been reported.

STORAGE

Store in a cool, dry place, away from direct light.  Keep out of reach of children

REFERENCES

Brenner S, Horwitz C. Possible nutrient mediators in psoriasis and seborrheic dermatitis. II. Nutrient mediators: essential fatty acids; vitamins A, E and D; vitamins B1, B2, B6, niacin and biotin; vitamin C selenI.U.m; zinc; iron. World Rev Nutr Diet 1988;55:165-182.

Congdon N, Sommer A, Severns M, et al. Pupillary and visual thresholds in young children as an index of population vitamin A status. Am J Clin Nutr 1995;61:1076-1082.

Coutsoudis A, Bobat RA, Coovadia HM, Kuhn L, Tsai W-Y, Stein ZA. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. Am J Public Health 1995;85:1076-1081.

Haller J, Lowik MR, Ferry M, Ferro-Luzzi A. Nutritional status: blood vitamins A, E, B6, B12, folic acid and carotene. Euronut SENECA investigators. Eur J Clin Nutr 1991;45 Suppl 3:63-82.

Hallfrisch J, Muller DC, Singh VN. Vitamin A and E intakes and plasma concentrations of retinol, b-carotene, and a-tocopherol in men and women of the Baltimore Longitudinal Study of Aging.

Am J Clin Nutr 1994;60:176-182.

Karter DL, Karter AJ, Yarrish R, et al. Vitamin A deficiency in non-vitamin-supplemented patients with AIDS: A cross-sectional study. J Acquir Immune Defic Syndr 1995;8:199-203.

Kowalski TE, Falestiny M, Furth E, Malet PF. Vitamin A hepatotoxicity: A cautionary note regarding 25, 000 I.U. supplements. Am J Med 1994;97:523-528.

Madhulika, Kabra SK, Talati A. Vitamin A supplementation in post-measles complications. J Trop Pediatr 1994;40:305-307.

Olson JA. Hypovitaminosis A: Contemporary scientific issues. J Nutr 1994;124 Suppl.1461S-1466S.

Pilch SM. Analysis of vitamin A data from the health and nutrition examination surveys. J Nutr 1987;117:636-640.

Reichman ME, Hayes RB, Ziegler RG, et al. Serum vitamin A and subsequent development of prostate cancer in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Cancer Res 1990;50:2311-2315.

Rothman KJ, Moore LL, Singer MR, Nguyen USDT, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med 1995;333:1369-1373.

Salonen JT, Salonen R, Lappetelainen R, Maenpaa PH, Alfthan G, Puska P. Risk of cancer in relation to serum concentrations of selenI.U.m and vitamins A and E: matched case-control analysis of prospective data. Br Med J (Clin Res Ed) 1985;290:417-420.

Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis 1994;19:489-499.

Sommer A. New imperatives for an old vitamin (A). J Nutr 1989;119:96-100.

Stephensen CB, Alvarez JO, Kohatsu J, Hardmeier R, Kennedy JI, Jr., Gammon RB, Jr. Vitamin A is excreted in the urine during acute infection. Am J Clin Nutr 1994;60:388-392.

Suan EP, Bedrossian EH, Jr., Eagle RC, Jr., Laibson PR. Corneal perforation in patients with vitamin A deficiency in the United States. Arch Ophthalmol 1990;108:350-353.

Underwood BA. Vitamin A deficiency as a public health problem & assessment methods. Arch Latinoam Nutr 1992;42:117S-122S.

Ward BJ, Humphrey JD, Clement L, Chaisson RE. Vitamin A status in HIV infection. Nutr Res 1993;13:157-162.

Ward BJ, Semba RD. Vitamin A and HIV infection. In: WATSON RR, ed. Nutrition and AIDS. Boca Raton: CRC Press, Inc. 1994:141-166.

Watson NJ, Hutchinson CH, Atta HR. Vitamin A deficiency and xerophthalmia in the United Kingdom. BMJ 1995;310:1050-1051.






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